Global assessment of haemostatic function - part II. Our experience with thrombin generation test using in thrombophilia patients

Česká verze

Authors: A. Hluší ¹; L. Slavík ¹; J. Úlehlová ¹; V. Krčová ¹; J. Zapletalová ¹; K. Indrák ¹
Authors place of work: Hemato-onkologická klinika FN LF UP Olomouc, 2Ústav lékařské biofyziky, pracoviště biometrie Lékařská fakulta UP Olomouc ¹
Published in the journal: Transfuze Hematol. dnes,16, 2010, No. 3, p. 121-125.
Category: Souhrnné práce, původní práce, kazuistiky

Summary

Generally used haemostatic tests do not cover the complexity of clotting system. Estimation of the potential to generate thrombin, which is the central enzyme in the blood coagulation, may correlate with thrombophilic fenotype. In our study we used thrombin generation test to evaluate the parameters of thrombin generation curve in thrombophilic patients and healthy blood donors groups. We compare results in asymptomatic and symptomatic subgroups of thrombophilic mutation carriers and also an influence of acquired risk factor on thrombin generation is assessed. The results show higher generation of thrombin in carriers of thrombophilic mutation which is statistically significant.

Key words:
thrombophilia, thrombin generation test, acquired risk factors

Zdroje

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