Inherited prothrombotic risk factors in children – when to investigate?


Authors: J. Blatný
Authors place of work: Oddělení dětské hematologie Fakultní nemocnice Brno
Published in the journal: Transfuze Hematol. dnes,17, 2011, No. 2, p. 69-71.
Category: Souhrnné práce, původní práce, kazuistiky

Summary

Incidence of VTE in children has increased significantly over the past twenty years. Published data however suggest that inhereted prothrombotic risk factors play a less significant role in paediatric venous thromboembolism than originally presumed. Inherited risk factors alone are deemed to be responsible for less than 15 % of VTE in children. Author critically reviews international as well as Czech national recommendations on the indication of inherited prothrombotic risk factors assesment in children.

Key words:
children, thrombosis, prothrombotic risk factors, hormonal contraceptives


Zdroje

1. Andrew M, David M, Adams M, et al. Venous thromboembolic (VTE) complications in children: first analyses of the Canadian registry of VTE. Blood 1994; 83 : 1251-1257.

2. Yang J, Paredes N, Chan AK. Antithrombotic therapy in children with venous thromboembolism. Hamostaseologie 2009; 29 : 80-87

3. Vu LT, Nobuhara KK, Lee H, et al. Determination of risk factors for deep venous thrombosis in hospitalized children. J Pediatr Surg 2008; 43 : 1095-1099.

4. Monagle P, Adams M, Mahoney M, et al. Outcome of pediatric thromboembolic disease: a report from the Canadian Childhood Thrombophilia registry. Pediatr Res 2000; 47 : 763-766.

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Štítky
Hematologie a transfuzní lékařství Interní lékařství Onkologie

Článek vyšel v časopise

Transfuze a hematologie dnes

Číslo 2

2011 Číslo 2

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